^ "Akynzeo (netupitant/palonosetron) capsules" (PDF).Archived from the original on 19 March 2020. ATC (2021) L’Anatomical Therapeutic Chemical Classification System (ATC), tradotto in italiano come Sistema di classificazione Anatomico Terapeutico e Chimico, è il sistema di codifica utilizzato per la classificazione sistematica dei farmaci ed è creato e manutenuto dal Centro Collaboratore dell’Organizzazione Mondiale della Sanità. Archived from the original on 18 October 2020. ^ "Akynzeo- netupitant and palonosetron capsule Akynzeo- fosnetupitant and palonosetron injection".^ "Fosnetupitant/Palonosetron (Intravenous Route)"."Netupitant-palonosetron (NEPA) for Preventing Chemotherapy-induced Nausea and Vomiting: From Clinical Trials to Daily Practice". ^ Aapro M, Jordan K, Scotté F, Celio L, Karthaus M, Roeland E (2022).2016 updated MASCC/ESMO consensus recommendations: prevention of nausea and vomiting following moderately emetogenic chemotherapy. NCCN Clinical Practice Guildelines in Oncology (NCCN Guidelines®): antiemesis (version 1.2021). 2016 Updated MASCC/ESMO consensus recommendations: prevention of nausea and vomiting following high emetic risk chemotherapy. The Anatomical Therapeutic Chemical code: a unique code assigned to a medicine according to the organ or system it works on and how it works. Single-dose netupitant/palonosetron versus 3-day aprepitant for preventing chemotherapy-induced nausea and vomiting: a pooled analysis. Lugano, Switzerland: Helsinn Therapeutics, Inc. Overview of chemotherapy-induced nausea and vomiting and evidence-based therapies. Akynzeo® (netupitant and palonosetron) prescribing information. The Author(s), under exclusive licence to Springer Nature Switzerland AG.Īdel N. In conclusion, netupitant/palonosetron is a simple, convenient and effective drug combination for the prevention of acute and delayed CINV in patients receiving chemotherapy that has a moderate to high potential to cause nausea and vomiting. Both the oral and intravenous formulations of the drug combination are well tolerated. In clinical trials, high proportions of patients who received netupitant/palonosetron (used in combination with the corticosteroid dexamethasone) prior to chemotherapy reported no vomiting, no requirement for rescue medication, and no significant nausea in the 5 days post chemotherapy. Chemical formula: CHFNO Molecular mass: 578.603 g/mol. Approved for use in the prevention of acute and delayed CINV in adults, netupitant/palonosetron is given orally or via intravenous infusion as a single dose prior to chemotherapy. Netupitant/palonosetron (NEPA Akynzeo ®) is a fixed-dose combination of two drugs (netupitant, a neurokinin 1 receptor antagonist and palonosetron, a serotonin 3 receptor antagonist) which target two different signalling pathways involved in the induction of vomiting. The fixed-dose combination is concordant with guideline recommendations and provides a simple and convenient option for prophylaxis against acute and delayed CINV in patients receiving highly or moderately emetogenic chemotherapy.Ĭhemotherapy-induced nausea and vomiting (CINV) is a common problem during cancer treatment. 2017 Empagliflozin/ metformin Reimbursed, 2016 Netupitant/ palonosetron. Both the oral and IV formulations of the drug combination are well tolerated. aTc authorization indication/icD condition approval/ reimbursement code date. Further, oral netupitant/palonosetron was found to be superior to palonosetron and non-inferior to aprepitant plus granisetron in preventing CINV in individual trials. In clinical trials, (fos)netupitant/palonosetron plus dexamethasone was associated with high complete response rates (no emesis and no rescue medication) in the acute, delayed and overall phases in patients receiving highly or moderately emetogenic chemotherapy, with efficacy maintained over multiple cycles. Administered as a single dose, (fos)netupitant/palonosetron (in combination with dexamethasone) is indicated for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Netupitant/palonosetron (NEPA Akynzeo ®), available in oral and intravenous (IV) formulations, is a fixed-dose combination of the neurokinin 1 (NK1) receptor antagonist netupitant (or the prodrug, fosnetupitant, in the IV formulation) and the second-generation serotonin 3 (5-HT 3) receptor antagonist palonosetron.
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